The United Auto Workers union began a nationwide strike against General Motors on Monday, with some 46,000 members walking off the job after contract talks hit an impasse.
The move to strike, which the Wall Street Journal described as the first major stoppage at GM in more than a decade, came after the manufacturer's four-year contract with workers expired without an agreement on a replacement.
Local union leaders met in Detroit "and opted to strike at midnight on Sunday," the UAW said on its Twitter account.
"This is our last resort," Terry Dittes, the union's lead negotiator with GM, told a news conference after the meeting. "We are standing up for the fundamental rights of working people in this country."
UAW officials said that the two sides remained far apart in the contract negotiations, with disagreements on wages, health care benefits, the status of temporary workers and job security.
"Our members have spoken; we have taken action; and this is a decision we did not make lightly," Ted Krumm, chair of the UAW's national bargaining committee, said in a statement.
"We are standing up for what is right," Krumm said.
Hours before the strike began, US President Donald Trump tweeted: "Here we go again with General Motors and the United Auto Workers. Get together and make a deal!"
GM's last major strike, according to the Journal, was in 2007 when 73,000 workers at more than 89 facilities walked off the job for two days.
In a statement, GM said it was "disappointing" that the UAW's leadership had decided to call the strike, saying it had presented a "strong offer" in contract negotiations.
"We have negotiated in good faith and with a sense of urgency. Our goal remains to build a strong future for our employees and our business," it said.
UAW's leadership had previously won overwhelming approval from its rank-and-file for a strike if it became necessary.
Workers at Ford and Fiat Chrysler agreed to extend their contracts, but GM management was informed on Saturday that the union would not extend its contract.
Earlier on Sunday, contract maintenance workers walked off the job at GM plants in Michigan and Ohio in a parallel dispute with contractor Aramark.
GM has enjoyed several years of strong sales, posting $11.8 billion in operating profits last year, prompting union officials to argue it is time to share the wealth with workers who have borne the brunt of downturns.
But the outlook for GM is less clear, with concerns growing that a recession may be in the offing amid protracted trade tensions.
GM announced last November it was effectively shuttering five plants in North America, including facilities in Michigan and Ohio that were "unallocated" for production.
Newspaper headline: GM auto workers strike in US