At least five people were killed and seven others were injured on Wednesday morning in a US drone strike in Pakistan's northwestern tribal region of South Waziristan, local media reported.

According to the reports, the US drone fired two missiles at a house located in the Babar Ghar village in the Wana district of South Waziristan, Pakistan's restive tribal region bordering Afghanistan.

The attack destroyed the compound completely and killed five people while leaving seven others injured.

Local people rushed to the site for rescue work, and a rise in causalities was feared as some people were still buried under the debris.

Media reports claimed that the compound was being used by the members of the banned militant organization Tehrik-e-Taliban Pakistan.

Wednesday's strike was the second of its kind in the current month. Earlier on April 14, a US unmanned plane targeted a house in North Waziristan and killed four people inside.

This was the 12th US drone attack in Pakistan's northwestern tribal areas this year, killing 72 people in total including two Al-Qaeda linked commanders.