Top seeds Novak Djokovic and Andy Murray both reached the third round of the ATP-WTA Cincinnati Masters on Wednesday.

Top seed Djokovic went through a hard first set before found his rhythm back in the second as he best Argentine Juan Monaco 7-5, 6-2.

"Between 4-1 and 4-5 were four quite bad games for me," he said.

Djokovic will meet Belgian qualifier David Goffin in the next round, who defeated Canada's Vasek Pospisil 7-5, 1-6, 7-6 (8/6).

Second-seed Murray upset Russian Mikhail Youzhny with a resounding 6-2, 6-3.

Murray needed just 70 minutes to see off his Russian opponent and move into a match with Julien Benneteau of France.

"I put a lot of pressure on myself to get through this one," Murray said. "With the US Open only a couple of weeks away, I need to stay in form."

Murray has won the Cincinnati event twice in 2008 and 2011.

Argentine seventh-seed Juan Martin del Potro put out Nikolay Davydenko 7-5, 7-5 while American John Isner beat French eighth-seed Richard Gasquet 7-6 (8/6), 6-2.

Women's top seed Serena Williams came from one set down to beat Canada's Eugenie Bouchard before winning 4-6, 6-2, 6-2.