Wales lock Luke Charteris has been ruled out of the Six Nations international against France in Cardiff on Friday with a knee injury, the Welsh Rugby Union said Tuesday.

His place in coach Warren Gatland's starting XV has been taken by Bradley Davies.

Gatland has made two other changes to the side that beat Scotland 27-23 at the Millennium Stadium 10 days ago, with wing Alex Cuthbert and flanker Dan Lydiate drafted into the New Zealander's ­run-on team.