The UK voted to leave the EU, with the Leave supporters beating Remain by 51.9 percent to 48.1 percent. The slight victory is likely to have opened a Pandora's box in Europe, pushing the continent into chaos.

A lose-lose situation is already emerging. The British pound fell 10 percent at one stage on Friday. The euro fell 3 percent.

David Cameron announced he would quit as British prime minister. Scotland may start a new independence referendum.

There are also calls in the Netherlands and France for a similar exit referendum.

The UK is just over 300 years old. In its heyday it was known as an empire on which the sun never set, with colonies all over the world.

Now it is stepping back to where it was.

Britons are already showing a losing mind-set. They may become citizens of a nation that prefers to shut itself from the outside world.

The Leave advocates had been calculating whether their pensions were guaranteed or  migrants were encroaching on their neighborhood. Bigger topics such as the country's aspirations or its global strategy were overlooked.

Britain has been a special member of the EU. It has not joined the eurozone, nor adopted the Schengen agreement. France and Germany have been resentful of Britain's half-hearted presence in the EU. In a sense, Britain's exit may be a relief for both sides.

However, such relief is in effect a major setback for European integration. Such setbacks don't happen in good times. Britain's exit reflects the general decline of Europe.

The world's center used to lie on the two sides of the Atlantic. Now the focus has shifted to the Pacific. East Asia has witnessed decades of high-speed growth and prosperity. Europe stays where it was, becoming the world's center of museums and tourist destinations. Unfortunately, Europe is also close to the chaotic Middle East. Waves of refugees flood into Europe, coinciding with increasing terrorist attacks.

Europe is not able to resolve the problems it is facing. The public are confused and disappointed and extremism is steading.

The Leave grouping beat out the Remain supporters by only 4 percentage points, which could have resulted from some temporary reasons. Is it really fair to decide Britain's future this way?

Such changes will benefit the US, which will lose a strong rival in terms of the dominance of its currency. Politically it will be easier for the US to influence Europe.

There is no direct political impact on Russia and China. For the Chinese people, who are at a critical time to learn about globalization and democracy, they will continue to watch the consequence of Britain's embracing of a "democratic" referendum.