Real Madrid and Barcelona will each head into the Clasico next weekend on the back of a defeat after La Liga's two title favorites were punished for slack performances on Saturday.

Zinedine Zidane made four substitutions at halftime but could not spark a lethargic Madrid into life as his team fell 1-0 at home to newly promoted Cadiz. 

Then two hours later on the opposite side of the city, Ronald Koeman tasted his first competitive loss as coach of Barcelona as they followed ­Madrid's example by being beaten 1-0 by Getafe at the Coliseum Alfonso Perez.

Madrid's was perhaps the more concerning display, the reigning champions managing just two shots on target against Cadiz, who could have scored more after Anthony Lozano's early strike. 

But Barca were not much better, with Lionel Messi strangely quiet and the team failing to rebound after Jaime Mata's penalty gave Getafe the lead in the second half.

For Madrid, there was an injury concern too as Sergio Ramos spent the second half in the stands with ice strapped around his left knee. 

Madrid said the injury was not serious but it puts in doubt Ramos' involvement in their first Champions League game against Shakhtar Donetsk on Wednesday, as well the Clasico three days later. 

A prolonged absence for Ramos would cap a deflating night for the champions, whose dreary display certainly hands an early boost to their title rivals. 

Even if Barcelona were unable to capitalize, Atletico Madrid had earlier beaten Celta Vigo 2-0, with Luis Suarez opening the scoring at Balaidos.

This is Cadiz's first season in the top flight in 14 years and their first victory over Real Madrid in 29. 

Eder Militao, Casemiro, Fede Valverde and Marco Asensio came on while a surprised-­looking Toni Kroos also departed in the second period, replaced by Luka Jovic. 

But Cadiz could have been three up in the first quarter of an hour as Ramos prevented Alvaro Negredo's finish from rolling in before Negredo created the opener. 

His cushioned header put through Lozano, who skipped beyond Madrid's sleepy defense and poked over the onrushing Thibaut Courtois. 

Madrid might have equalized in the second half as Vinicius Junior headed wide of an open goal and Karim Benzema rattled the crossbar with a long-range shot. But Cadiz were not overly troubled. 

Getafe were never really hanging on either, even if Barcelona went close to an equalizer, Messi hitting the post and then driving a loose ball wide in injury time. Antoine Griezmann also ballooned over when put through in the first half.